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The composition of one tablet of Belara includes 2 mg of chloromadinone acetate and 30 μg of ethinylestradiol.Additional components: lactose monohydrate, K30 povidone, corn starch, magnesium stearate.Composition of the film shell: macrogol 6000, hypromellose, talc, lactose monohydrate, propylene glycol, titanium dioxide, red iron oxide dye.Form of issue
Contraceptive pills Belara covered with a light pink shell, round, biconvex with a color white core. 21 such a tablet in a blister, one or three blisters in a pack of cardboard.pharmachologic effect
Combined preparation for contraception, taken orally.Prolonged use of the drug leads to a decrease in the secretion of follicle-stimulating hormone and lyutenizing hormone, and, consequently, to suppression of the ovulation process. Simultaneously, there is proliferation and secretory transformation of the endometrium, preventing the fixation of a fertilized egg. The viscosity of mucous secretions from the cervix increases, which passes with difficulty of passage of male sex cells through the cervical canal and inhibition of their mobility.The chloromadinone acetate that enters the drug is a gestagen that has antiandrogenic properties. Its effect is based on the ability to compete with androgens in specific receptors, weakening the effect of androgens. The Perl index (the probability of getting pregnant within 12 months) varies between 0.291-0.698 and depends on the thoroughness of the womans adherence to the regimen.To completely block ovulation, approximately 1.7 mg of chloromadinone acetate is required daily. The required dosage per cycle is 25 mg.Pharmacokinetics
Chlormadinone acetate. Quickly and completely absorbed. The maximum concentration occurs an hour and a half. 95% binds to human blood proteins, mainly albumin.In the process of transformation, many metabolites are formed, the main ones being 3-beta and 3-alpha-hydroxy-chloromadinone acetate.The average half-life of blood is 34 hours. Chlormadinone acetate and its metabolites are excreted in approximately equal amounts with urine and through the intestine.Ethinyl estradiol. Quickly and almost completely absorbed from the intestine, reaching a maximum concentration in the plasma in an hour and a half. Absolute bioavailability is about 40%.About 98% of the substance binds to blood proteins. Ethinyl estradiol is transformed by hydroxylation of the aromatic ring. The main derivative is 2-hydroxy-ethynylestradiol.The average half-life of ethinylestradiol from the blood is 13 hours. It is excreted by the kidneys and with feces in the proportion of 2: 3.Indications for use
The need for oral contraception.
Usually, overdose does not observe severe toxic effects. Symptoms: vomiting, nausea, bloody discharge from the vagina.Treatment: symptomatic. There is no selective antidote.
Keep away from children and store at temperatures up to 25 degrees.Shelf life - two years.special instructions
The drug does not affect the ability to drive.
Analogues of Belara: Yaz, Yaz Plus, Jeanine, Lindynette 20, Logest, Marvelon, Mercilon, Midiana, Novinet , Regulon, Rigevidon, Yarina, Yarina Plus.In pregnancy and lactation
In the period of lactation or pregnancy, it is contraindicated to use the drug Belara.
The doctors' comments on the contraceptive pill of Belara show that the drug has proven itself as a reliable contraceptive. Reviews about Belara are also reported on frequent unwanted phenomena: women gain weight, for the skin the drug is also harmful (many have to subsequently take funds for acne).'
|The purpose of the medication||Contraception|