CEFOTAXIME (Claforan) - is an antibiotic used to treat a number of bacterial infections. Specifically it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis. It is given either by injection into a vein or muscle. Cefotaxime was discovered in 1976 and came into commercial use in 1980. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.
Original from Russian Kraspharma. Manufacturer may vary.
All packs are air tight sealed and expire up to 05.2021.
Photo of the product is for illustation purpose only and may vary.
Historically, Cefotaxime has been considered to be comparable to ceftriaxone (another third-generation cephalosporin) in safety and efficacy for the treatment of bacterial meningitis, lower respiratory tract infections, skin and soft tissue infections, genitourinary tract infections, and bloodstream infections, as well as prophylaxis for abdominal surgery. The majority of these infections are caused by organisms traditionally sensitive to both cephalosporins. However, ceftriaxone has the advantage of once-daily dosing, whereas the shorter half-life of cefotaxime necessitates two or three daily doses for efficacy. Changing patterns in microbial resistance suggest cefotaxime may be suffering greater resistance than ceftriaxone, whereas the two were previously considered comparable. Considering regional microbial sensitivities is also important when choosing any antimicrobial agent for the treatment of infection.
Intramuscularly and intravenously.
For intramuscular injection, 500 mg of the drug is dissolved in 2 ml (respectively 1 g in 4 ml) of sterile water for injection or Lidocaine. Enter deep into the gluteal muscle. An intramuscular injection also uses a 1% Lidocaine solution (500 mg - 2 ml, 1000 mg - 4 ml) as a solvent.
For intravenous administration, 500-1000 mg of cefotaxime is dissolved in 10 ml of sterile water for injection. Enter slowly for 3-5 minutes.
When determining glucose in urine by a non-enzymatic method (for example, the Benedict method), false-positive results are possible. With caution, appoint persons who drive vehicles and engage in activities that require increased concentration of attention and rapid motor reaction.
SIDE EFFECTS AND PRECAUTIONS
Overdose Symptoms: convulsions, encephalopathy (in the case of large doses, especially in patients with renal failure), tremors, increased neuromuscular irritability. Treatment: symptomatic therapy.
Allergic reactions: urticaria, chills or fever, rash, itching, swelling of the face, laryngeal edema, bronchospasm, eosinophilia, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), bullous rash.
From the digestive system: nausea, vomiting, diarrhea or constipation, flatulence, abdominal pain, impaired liver function (increased activity of "liver" transaminases, alkaline phosphatase, hepatitis, jaundice, blood in the feces, hypercreatininemia, hyperbilirubinemia), stomatitis, glossitis, pseudomembranous colitis.
From the hemopoietic organs: leukopenia, neutropenia, granulocytopenia, thrombocytopenia, hemolytic anemia, hypocoagulation, agranulocytosis. From the urinary system: impaired renal function (azotemia, increased urea in the blood, oliguria, anuria, interstitial nephritis), hypercreatinemia.
From the nervous system: headache, dizziness, fainting, cramps, fatigue, encephalopathy (when prescribed in high doses), motor disorders, weakness.
From the cardiovascular system: lowering blood pressure, potentially life-threatening arrhythmias after rapid bolus injection into the central vein.
Laboratory indicators: false positive Coombs test.
Local reactions: inflammatory reaction at the injection site, including phlebitis and thrombophlebitis, soreness along the vein, soreness and infiltration at the site of intramuscular injection, redness of the skin.
Other: superinfection (in particular, candidal vaginitis), excessive growth of cefotaxime-resistant organisms. In the treatment of borreliosis: the Yarish-Herksheimer reaction (during the first days of treatment), skin rash, itching, fever, leukopenia, increased activity of liver transaminases, shortness of breath and discomfort in the joints.
Store in dry place at room temperature. Do not exceed storage temperature higher than 25 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.
Ask us any questions about CEFOTAXIME.
|The purpose of the medication||Antibacterial|