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Midiana #21

Midiana #21

$28.90

(In stock)

  • Midiana #21 Midiana #21

Midiana #21

Quick Overview

In one tablet, covered. shell, contains 3 mg of drospirenone, 0.03 mg of ethinyl estradiol.As auxiliary substances used:    magnesium stearate (weight - 0.8 mg);    lactose monohydrate (48 mg);    corn starch (16 mg);    pregelatinized corn starch (9.6 mg);    Povidone To 25 (1.6 mg);    film shell (2 mg) - Opadry II white, and Colorcon 85G18490, which includes polyvinyl alcohol, soy lecithin, talc, titanium dioxide E 171 and macrogol No. 3350.

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$28.90

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Details

Midiana user manual

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Composition

Form of issue

It is produced in white round biconvex round capsules, they are covered with film cover, on one side they have engraving "G63". For 21 tablets in a blister, 1, 3 blisters in a pack.

pharmachologic effect

Has a contraceptive effect with antiandrogenic and antimineralocorticoid properties.

Pharmacodynamics and pharmacokinetics

The contraceptive effect is based on the interaction of factors, among which the most important are inhibition of ovulation and structural and functional changes in the endometrium.Midianaa is a combined oral contraceptive due to such active substances as ethinyl estradiol and drospirenone. In addition, drospirenone in therapeutic dose has antiandrogenic and weak antimineralocorticoid properties, nevertheless, does not possess estrogenic, glucocorticoid, antiglucocorticoid activity, which gives drospirenone similarity in pharmacological profile to natural progesterone.Concerning pharmacokinetics: biotransformation of drospirenone and einilestradiol occurs in different ways. Drospirenone, when taken orally, is not completely absorbed, bioavailability is within 76-85% regardless of nutrition. Its maximum concentration after the first dose in the serum is 37 nanograms per ml in a few hours, in the first cycle, an equilibrium concentration of 60 nanograms per ml is established after 7-14 hours. Reduction in serum concentration occurs in 2 phases by binding to serum albumin.Metabolites of drospirenone are represented by acid forms formed during the opening of the lactone ring. The average apparent volume of distribution is about 3.7 liters per kilogram, the speed of metabolic. clearance - 1.5 ml / min / kg. The elimination process occurs exclusively in trace amounts in unmodified form, the metabolic products are excreted by the kidneys and through the intestine in an approximate ratio of 1.2: 1.4 with a half-life of 40 hours.In contrast to drospirenone, ethinyl estradiol is absorbed quickly and completely when taken orally, with an absolute bioavailability of 45%. The maximum concentration after the first dose is reached after several hours and is 30 μg. It has been established that a significant 1-pass effect occurs with a high individual variability, the apparent volume of the distribution is usually 5 liters per kilogram, approximately 98% of the compounds bind to plasma proteins. Ethinyl estradiol is able to induce the synthesis of globulin, binding sex hormones and transcortin in the liver. Metabolism occurs completely with the rate of metabolic clearance in 5 ml / min / kg, 0.02% of the dose enters the breast milk, the metabolic products are excreted by the kidneys and by the intestine in a stable ratio of 4 to 6 with the half-life of excretion of 1 day and the elimination half-life of 20 hours.

Indications for use

Contraception. Additional benefits for patients with puffiness, hormone-dependent fluid retention or weight gain, with seborrhea and acne.

Contraindications

Side effects

Instructions for use (Method and dosage)

Take the tablets inside, you can drink it with water (a small amount), every day (starting from the 1st day of the natural menstrual cycle, that is, menstrual bleeding) approximately at the same time in the sequence indicated on the blister: one tablet for 3 weeks, then a 7-day interval is required for the onset of menstrual bleeding.When replacing another combined oral contraceptive, vaginal ring, or transdermal patch, it is preferable to begin using Midiana the day after the last pill is consumed or on the day of removal of any of the previously used drugs.Midiana tablets can be taken from a mini-saw every day, on the day of removal of the implant or other intrauterine contraceptive, on the next injection day, while it is advisable to apply additional barrier methods of contraception in the first week.If the pregnancy was interrupted in the 1st trimester, then the reception is started immediately without additional contraceptive measures, if the pregnancy is interrupted in the 2nd trimester or the baby is born, then the reception begins in 3-4 weeks. A larger interval requires the use of additional barrier methods of contraception in the first week. If there is sexual intercourse, then first completely eliminate pregnancy or wait for the first menstruation.

The scheme for taking missed tablets

Overdose

There have been no cases of overdose. Possible symptoms: nausea, vomiting, spotting or bleeding from the vagina. Prescribe symptomatic treatment. There is no specific antidote.

Interaction

Storage conditions

Inaccessible to children, dark place, at a temperature of no more than 25 ° Celsius.Shelf life Two years.

special instructions

If you take any of the drugs listed in the first 3 items of the "Interaction" section with this medicine, then you need to use barrier methods of contraception or completely switch to other contraceptives. If drugs containing active substances that affect microsomal liver enzymes are used, non-hormonal contraceptives should be used for 4 weeks after their withdrawal. When the concomitant drug is started at the end of the contraceptive package, the next packaging of the contraceptive is taken without a 7-day interval.

Midiana and overweight

No set of excess weight, sometimes there is a withdrawal of excess fluid. The drug does not affect the body weight. If there is such a side effect, it is better to consult a doctor.

With antibiotics

When taking antibiotics (except: Rifampicin, Griseofulvin), it is also necessary to temporarily resort to barrier methods of contraception for at least another 7 days after their withdrawal.

In pregnancy and lactation

During pregnancy and lactation, Median is contraindicated. If there was a pregnancy on the background of contraception, then immediately cancel the drug.There is little information on the lack of teratogenic effects and the increased risk to the child and woman during labor with the unintentional intake of combined oral contraceptives. In addition, they affect lactation, can reduce the amount and change the composition of breast milk, which can have a harmful effect on the child.

Reviews of Midiana

The doctors' comments about the Midiana are positive, they confirm the effectiveness of the drug as an oral contraceptive, so the drug is prescribed quite often. Regarding the reviews of patients - on the forums you can find a lot of different opinions. In most cases, they indicate the benefits of the drug: there is no effect on weight, skin, libido, it is also said about a high level of reliability, with one significant drawback - the drug can not be found in all pharmacies. However, in isolated cases, there are statements about the severity of addiction, headaches, digestive disorders, and others.

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Additional Information

SKU fh446
The purpose of the medication Contraception
Weight kg. 0.05

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