SPIRONOLACTONE (Aldactone, Spiractin, Verospiron)
Original from various Russian pharmaceutical companies.
All packs are air tight sealed and expire up to 09.2022.
Photos of the product are for illustation purpose only and will vary according to the manufacturer.
Spironolactone is a potassium-magnesium diuretic. It is a competitive aldosterone antagonist on the effect on the distal nephron (competes for binding sites on the cytoplasmic protein receptors, reduces the synthesis of permeases in the aldosterone-dependent section of the collecting tubes and distal tubules) reduces titratable acidity of urine. Increased diuresis causes a hypotensive effect, which is not constant. The hypotensive effect does not depend on the level of renin in the blood plasma and does not manifest itself in normal blood pressure. The diuretic effect is manifested at 2-5 days of treatment.
25-100 mg per capsule, 20-30 capsules per pack.
Spironolactone - 25-100 mg.
Corn Starch - 260 mg
Magnesium Stearate - 85 mg
Capsule shell composition: Titanium Dioxide and Medical Gelatin
The optimal dosage regimen is determined by your doctor. It is necessary to strictly observe the compliance of the used dosage with the indications for use. Set individually, depending on the severity of disorder(s) of water and electrolyte metabolism and hormonal status. Edematous syndrome - 100-200 mg per day (on some oncassions - 300 mg per day) in 2-3 doses for 14-21 days. Dose adjustment should be carried out taking into account plasma potassium concentration. If necessary, the course is repeated every 10-14 days. With pronounced hyperaldosteronism and reduced plasma potassium content - 300 mg per day in 2-3 doses.
Use caution when AV blockade (possibility of amplification due to the development of hyperkalemia), decompensated liver cirrhosis, surgery, taking drugs that cause gynecomastia while taking local and general anesthetics in elderly patients. Against the background of the use of spironolactone it is not necessary to prescribe drugs containing potassium, as well as other diuretics that cause potassium retention in the body. The use of spironolactone with carbenoxolone, which causes sodium retention should be avoided. During the period of treatment should be carried out periodic determination of the content of electrolytes and urea in the blood. When using spironolactone in combination with other diuretic or antihypertensive agents, the dose of the latter is recommended to be reduced. When using spironolactone simultaneously with digoxin, it may be necessary to reduce both the saturating and maintenance doses of the latter.
On the part of the digestive system: nausea, vomiting, abdominal pain, gastritis, ulceration and bleeding in the digestive tract, intestinal colic, diarrhea or constipation. CNS: dizziness, drowsiness, lethargy, headache, lethargy, ataxia. On the part of the metabolism: an increase in the concentration of urea, hypercreatininemia, hyperuricemia, impaired water-salt metabolism and CSR (metabolic hypochloraemic acidosis or alkalosis). From the hemopoietic system: megaloblastosis, agranulocytosis, thrombocytopenia. On the part of the endocrine system: with long-term use - gynecomastia, erectile dysfunction in men in women, dysmenorrhea, amenorrhea, menopausal metrorrhagia, hirsutism, coarsening of the voice, breast tenderness, and breast carcinoma. Allergic reactions: urticaria, maculopapular and erythematous rash, drug fever, pruritus. Other: muscle spasms, reduced potency.
Store in dry place at room temperature. Do not exceed storage temperature higher than 20 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.
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