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Triquilar pills #21

Triquilar pills #21

$30.41

(In stock)

  • Triquilar pills #21 Triquilar pills #21

Triquilar pills #21

Quick Overview

1 tablet contains the active ingredients levonorgestrel / ethinyl estradiol in the following proportions: 40/75 μg; 30/50 μg and 30/125 μg, respectively.Secondary ingredients: lactose monohydrate, calcium carbonate, red and yellow iron oxide pigment, glycerol 85%, corn starch, montanglylic wax, magnesium stearate, povidone 25,000 and 700,000, macrogol 6000, sucrose, titanium dioxide, talc.

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Triquilar user manual

You can buy Triquilar pills online

Composition

1 tablet contains the active ingredients levonorgestrel / ethinyl estradiol in the following proportions: 40/75 μg 30/50 μg and 30/125 μg, respectively.Secondary ingredients: lactose monohydrate, calcium carbonate, red and yellow iron oxide pigment, glycerol 85%, corn starch, montanglylic wax, magnesium stearate, povidone 25,000 and 700,000, macrogol 6000, sucrose, titanium dioxide, talc.

Form of issue

The drug Triquilar is released in the form of tablets in three different proportions of active ingredients: 5 pieces - 40/75 μg 6 pieces - 30/50 mcg 10 pieces - 30/125 mcg. In total, one blister (numbered by arrows) includes 21 tablets. One package can contain 1 or 3 blisters.

pharmachologic effect

Levonorgestrel

When taken orally, levonorgestrel is absorbed for a relatively short time and almost completely. Serum Cmax is observed after about 60 minutes and is 2.3 ng / ml. One-time internal reception of 0.125 mg of levonorgestrel (the highest concentration of the substance in tablets) together with 0.33 mg of ethinyl estradiol leads to the determination, after about an hour, of its highest serum level at 4.3 ng / ml. Bioavailability of levonorgestrel, when taken orally, is almost 100%.Levonorgestrel forms a bond with plasma albumin and globulin, which connects sex hormones (SHBG). Only 1.4% of the total plasma content is in free form, 55% are associated with SHBG and about 44% with albumin. Due to the induction of replication of the binding protein by ethinyl estradiol, a part of the substance associated with SHBG increases, and the other part, bound to albumin, decreases. After a one-time oral intake of the highest dose of levonorgestrel for Triquilar, its Vd is approximately equal to 128 liters.Metabolism levonorgestrel is complete and passes all the typical metabolic pathways for steroids. After a one-time oral administration of the highest dose of levonorgestrel for Triquilar, the serum clearance is approximately 1.0 ml / min / kg.Plasma saturation with levonorgestrel undergoes a two-phase reduction process. T1 / 2 in the terminal phase lasts approximately 22 hours. Levonorgestrel is excreted with bile and urine (1: 1) exclusively in metabolized forms, with T1 / 2 about 24 hours.The pharmacokinetics of levonorgestrel depends on the serum level of SHBG, which doubles for the course of taking the drug (21 days). With daily administration of Triclvir, the plasma level of substances increases approximately twice, and the equilibrium concentration is observed in the second phase of the course. The clearance rate and volume of distribution, at equilibrium concentration, are accordingly reduced by 0.5 ml / min / kg and up to 52 liters.

Ethinylestradiol

The internal reception of ethinylestradiol leads to its rapid and complete absorption. Serum Cmax is observed after 80 minutes and is 116 ng / ml. In the process of absorption and initial passage through the liver, ethinylestradiol metabolism occurs, which determines its bioavailability at about 45%, with individual differences within the range of 20-65%.In the mucosa of the small intestine and in the liver, ethinyl estradiol undergoes the process of presystemic conjugation. The main pathway of metabolism is aromatic hydroxylation. Plasma clearance is 2.3-7 ml / min / kg.Ethinyl estradiol binds to albumin (nonspecifically) by 98%. Enters an inductor in the replication of the GSPN. Vd is equal to 2.8-8.6 l / kg.The decrease in serum concentration of ethinyl estradiol undergoes two phases, the first of which proceeds with T1 / 2 about 60 minutes, and the second from 10 to 20 hours. From the body are excreted, with the help of the liver and kidneys (in a ratio of 6: 4), only metabolic products, with T1 / 2 approximately 24 hours.After 7 days, an equilibrium concentration is observed.

Indications for use

The drug Triquilar is prescribed for the purpose of contraception (contraceptive).

Contraindications

Carefully

Side effects

Triquilar, instructions for use (Method and dosage)

Packaging of the product includes instructions for the use of Triquilar and a round blister (with arrows) with 21 tablets, which are located along the course of the circle. Receipt of tablets must start from the sector with the index "Beginning", then, following the direction of the arrows, continue daily taking the nearest tablet. Tablets are taken orally (orally), preferably at the same time, with water. The duration of administration corresponds to the number of tablets - 21 days, followed by a 7-day break with withdrawal bleeding. Typically, bleeding occurs 2-3 days after taking the final blister tablet and may not stop before the first pill is taken from the next package, which begins to drink just after the 7-day interval.

Beginning of taking Triquilar tablets

Recommendations for missing tablets

Skip reception on the first week

It is necessary to take the final missed tablet as early as possible (even in the case of simultaneous intake of two tablets). The next pill is taken at one time. For 7 days, use the BC. It should be remembered about possible pregnancy during sexual intercourse for 7 days before missing tablets.

Skip reception in the second week

It is necessary to take the final missed tablet as early as possible (even in the case of simultaneous intake of two tablets). The next pill is taken at one time. Given the correct previous week of Triquilar, there is no need to use BC. In case of admission disorders during the first week or when more than one tablet is missed, it is necessary to use the BC for 7 days.

Skip reception in the third week

Recommendations for diarrhea and / or vomiting

In the event of diarrhea and / or vomiting, within 4 hours after taking the pill, it is possible to reduce the contraceptive effectiveness, due to a violation of absorption of the drug. It is necessary to use the BC and be guided by the recommendations given in case of missing one tablet.

Restructuring of the menstrual cycle

To delay the start of the menstruation cycle, after the end of using the current blister, take the last 10 tablets (for 10 days) from the next blister. Consequently, the cycle can be extended for up to 10 days, until the end of the second blister (there may be breakthrough bleeding or spotting). The resumption of regular Triquilar administration takes place after a mandatory 7-day interval.To transfer the day of the beginning of the cycle of menstruation for the desired day of the week, it is necessary to shorten the nearest interval in taking the tablets for the required number of days. In this case, the risk of non-occurrence of bleeding cancellation increases, respectively, shortening the interval. In this case, when using a second blister, breakthrough bleeding or spotting is possible.

Overdose

Symptoms of overdose are manifested by nausea, spotting bloody discharge, vomiting, metrorrhagia.Symptomatic treatment is indicated.

Interaction

Pyrazolone derivatives, sulfonamides, can enhance the metabolic transformations of steroid hormones that make up Triquilar.Long-term therapy with drugs (barbiturates, phenytoin, primidon, rifampicin, carbamazepine, griseofulvin, oxcarbazepine, felbamate, topiramate, ritonavir, hypericum drugs), inducing hepatic enzymes, which increases the clearance of hormones (genital), may cause a decrease in Triclvir's contraceptive effectiveness or breakthrough bleeding.Parallel use of antibiotics from a number of tetracyclines and ampicillins can reduce the contraceptive protection of triclvir, due to a decrease in intrahepatic circulation of estrogens, which leads to a reduction in the content of ethinyl estradiol.Triquilar can affect the metabolism of other drugs (eg, Cyclosporine), which can lead to a change in their plasma and tissue concentrations.

Storage conditions

Tablets are stored in the original packaging, at room temperature (up to 25 ° C).

Shelf life

The drug remains effective for 5 years.

special instructions

When using antibiotics of a number of tetracyclines and ampicillins, and also in the next 7 days, it is necessary to use BC.The following are some of the risk factors and disease states, the presence of which, in the appointment of Triquilar, requires an individual approach in each case, taking into account the possible risk / benefit for the woman. These questions should be resolved before the COC is started and inform the woman about the likelihood of the manifestation or weighting of these conditions, as well as the possible need, in the event of complications, the elimination of tricvilar in the future.

The cardiovascular system

When taking Triquilar, there was a slight increase in the frequency of thromboembolism and vascular thrombosis.Also, when taking COC, there are rare references to cases of thrombosis of other vessels of the circulatory system, such as: renal, mesenteric, hepatic, retina and its branches. In this case, communication with the use of COCs has not been proven.If symptoms of cerebrovascular disorders or thrombosis are detected: unilateral swelling or pain in the leg severe sudden chest pain dizziness sudden shortness of breath strong unreasonable cough any headache (strong, unusual, prolonged) of unknown origin diplopia spontaneous full or partial loss of vision aphasia or incomprehensible speech loss of consciousness weakness convulsive attack sudden one-sided loss of sensitivity lack of coordination symptoms of an "acute abdomen", you should stop taking Triquilar and consult a doctor.

The risk of thromboembolism and thrombosis is increased when:

Neoplasms

In some studies, there are reports of an increased risk of cervical and breast cancers occurring with prolonged use of COC, albeit with an unproven causal relationship. This increase in the risk of malignant neoplasm formation is possible due to the early diagnosis of cancer related to cervical and breast examinations in women prior to the appointment of COCs. It is also worth noting that breast neoplasms in patients who ever used COCs were significantly less pronounced than those who did not take them.In isolated cases, the occurrence of hepatic tumors was observed when taking COC. In case of manifestations of liver enlargement, severe pain in the abdomen, symptoms of intra-abdominal bleeding, the possibility of a liver tumor should be taken into account when establishing a differential diagnosis.

Other morbid conditions

Against the background of the use of Triquilar, if a woman has hypertriglyceridemia (including a family history), pancreatitis may occur.Some insignificant increase in blood pressure was typical of many women using COC. In rare cases, a significant increase in blood pressure was noted, which required the abolition of the contraceptive and the transition to the treatment of hypertension. In case of positive reaction of the patient to therapy and stabilization of blood pressure, it is possible to resume the COC administration.Below are the disease states that progress or develop both during pregnancy and when using COC, although with an unproven causal relationship: systemic lupus erythematosus, itching due to cholestasis, jaundice, cholelithiasis, porphyria, uremic hemolytic syndrome, chorea Sydenham loss of hearing due to otosclerosis, Crohn's disease, herpes of pregnant women, ulcerative colitis.Liver pathologies can cause cancellation of COC, before stabilization of liver function.At the first time diagnosed cholestatic jaundice, against the background of previous COC or pregnancy, it is necessary to refuse the use of this contraceptive.Although COCs affect glucose tolerance and insulin resistance, there is no need to adjust the regimen in patients with diabetes who use low-dose COCs (up to 0.05 mg ethinyl estradiol). Despite this, women with diabetes and taking COCs are required to undergo regular examinations of their condition.Receiving Triquilar with a woman's inclination to chloasma, requires her to be careful while staying in the sun and other ultraviolet exposure.

Laboratory Tests

The use of COC can influence a number of results of individual laboratory tests, including the level of plasma transport proteins, adrenal parameters, hepatic and renal function, thyroid gland, carbohydrate metabolism, fibrinolysis parameters and coagulation. These changes, as a rule, do not go beyond the limits of normal indications.

Effects on the menstrual cycle

When taking COC, irregular bleeding may occur (breakthrough bleeding or spotting), especially during the initial months of taking the tablets.In this regard, to conduct a reliable assessment of these bleedings can only be after the adaptation phase, usually consisting of three cycles.In the case of developing or recurring irregular bleeding, after previous permanent cycles, a comprehensive examination is necessary to exclude pregnancy or malignant neoplasms.Some women taking Triquilar bleeding cancellation during the 7-day interval in taking the pills does not develop. If this Triquilar was taken strictly according to instructions, without missing pills and other negative factors, then the onset of pregnancy is unlikely. However, before the next blister is taken, it is better to exclude a possible pregnancy.

Medical examinations

If the woman decided to use the COC, including Triquilar, she needs to undergo comprehensive gynecological and general medical examination (including cytology of cervical mucus and examination at the mammalogy), and also to exclude the pathology of blood coagulation and possible pregnancy.If Triquilar is used for a long period of time, checkups should be performed every 6 months.A woman should be warned that the use of COCs does not protect against sexually transmitted diseases, including HIV infection (AIDS).

Analogues

In pregnancy and lactation

Tablets Triquilar not appointed during breastfeeding and pregnancy.

Reviews of Triquilar

Reviews of Triquilar, as in principle and other contraceptives of this group, a priori can not bear only a positive or negative assessment of their effectiveness and safety of admission. Combined oral contraceptives are selected and fully suitable only for a certain category of women, due to the characteristics of their body, the level of hormones, concomitant diseases, bad habits, etc.Therefore, in the pharmaceutical market there are many analogs of the COC, one of which is exactly the right one for a woman. Based on the above, it is worth recalling that you can not independently prescribe a contraceptive drug, leave this decision to the discretion of a specialist and only after conducting a comprehensive survey.

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Additional Information

SKU fh744
The purpose of the medication Contraception
Weight kg. 0.05

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