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Yarina Plus tabs #28

Yarina Plus tabs #28


(In stock)

  • Yarina Plus tabs #28 Yarina Plus tabs #28

Yarina Plus tabs #28

Quick Overview

    The active Yarina Plus contains 3 mg of drospirenone, 30 μg of ethinylestradiol, 451 μg of calcium levometholate. Additional substances: microcrystalline cellulose, lactose monohydrate, giprolose, sodium croscarmellose, magnesium stearate, orange varnish.    The composition of one vitamin supplementary pill of Yarina Plus contains 451 μg of calcium levometholate. Additional substances: microcrystalline cellulose, lactose monohydrate, giprolose, sodium croscarmellose, magnesium stearate, light orange varnish.

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Yarina Plus

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Form of issue

pharmachologic effect

Replenishes the lack of folate, has a contraceptive and estrogen-progestational effect.

Pharmacodynamics and pharmacokinetics


Monophasic low-dose combined oral estrogen-progestational contraceptive, which includes active and supplementary tablets with calcium levometholate.The contraceptive effect of Yarina Plus is carried out by suppressing ovulation and increasing the viscosity of the cervical mucus. In patients taking similar oral contraceptives, the cycle is normalized, the soreness, intensity and duration of bleeding decrease, and as a result, the risk of iron deficiency anemia decreases. There are also data on a decrease in the likelihood of the appearance of endometrial and ovarian neoplasms.Drospirenone demonstrates an antimineralocorticoid effect and prevents fluid retention, which can reduce body weight and reduce the risk of peripheral edema. It has antiandrogenic activity and helps to reduce acne, reduce fat and hair. These facts should be considered when choosing a contraceptive for women with a delay in fluid hormonal nature, as well as with acne.Levomefolat calcium is an active form of folate, digestible better than folic acid. It is necessary to meet the increased need for folate during pregnancy and during lactation. The presence of calcium levomefolate in a contraceptive oral means reduces the likelihood of a fetal neural tube in the event that a pregnancy occurs after the abolition of contraception.


DrospirenoneAfter intake, it is absorbed quickly. The highest level in the blood is achieved after an hour and a half. Bioavailability is 76-85%. It binds to albumin and does not react with the hormone-binding globulin. Only 3-5% of the substance circulating in the blood is in free form. With the systematic use of the drug, the concentration of drospirenone in the blood increases 2-3 times. Most metabolites are acid derivatives of drospirenone. They are excreted through the kidneys and intestines.EthinylestradiolQuickly absorbed after ingestion. The maximum level in the blood is reached after an hour and a half. Food reduces bioavailability by 25%. Ethinyl estradiol reacts actively with blood albumin. It is transformed in the liver by aromatic hydroxylation with the production of numerous metabolites. It is excreted as metabolic products with urine and feces. The elimination half-life reaches 24 hours.Calcium levometholateQuickly absorbed after getting into the digestive tract. In the form of L-5-methyl-THF it is delivered to organs and peripheral tissues. Folates are involved in the biosynthesis of thymidine, purines, DNA, RNA, methionine and glycine. It is excreted mainly by the kidneys in the original form and in the form of metabolites.

Indications for use


Side effects

Instructions for use Yarina Plus (Method and dosage)

Tablets are taken orally in the order indicated on the package, every day at the same time, washed down with water and not chewed.

Yarina Plus, user's manual

The reception begins on the first day of the cycle (the first day of menstrual bleeding). Use continuously one tablet a day for 4 weeks. The use of tablets from the next pack starts immediately after the completion of the previous one.With symptoms of vomiting or diarrhea within 5 hours after taking the drug, the absorption of the active substance becomes ineffective. In the described case it is necessary to apply additional contraceptive measures.Yarina Plus is not used at the onset of menopause.The drug is contraindicated for women with severe disorders of kidney and liver function.


Signs of an overdose: vomiting, nausea, spotting.Treatment of overdose: selective antidote is not known, it is necessary to carry out symptomatic therapy. Calcium levometholate and its derivatives do not harm the body, regardless of the amount taken.


The use of drugs that stimulate microsomal hepatic enzymes, can lead to an increase in the excretion of sex hormones. Such medicines include: barbiturates, phenytoin, primidone, carbamazepine, rifampicin and others.Some antibiotics (penicillins and tetracycline) are able to reduce the concentration of ethinyl estradiol.In the period of application of drugs acting on microsomal hepatic enzymes, and 4 more weeks after their withdrawal, the barrier method of contraception should be used additionally.During the application of antibiotics (Rifampicin and Griseofulvin do not cause such a need), and even within a week after their withdrawal, it is recommended to use the barrier method of contraception in addition.A number of drugs reduce the folate content in the blood or weaken the effectiveness of calcium levomefolate by blocking the enzyme dihydrofolate reductase (Trimethoprim, Methotrexate, Triamteren and Sulfasalazine), reducing folate absorption (Kolestyramin) or by unclear mechanisms (Phenobarbital, Carbamazepine, Primidone, Phenytoin, Valproic Acid).Folates are able to change the pharmacokinetic parameters of antiepileptic drugs, methotrexate, pyrimethamine, which is accompanied by a decrease in the therapeutic effect of the latter.

Storage conditions

Store at room temperature. Keep away from children.Shelf life - Three years.

special instructions


The use of the drug before menarche is prohibited.

In pregnancy and lactation

The drug is prohibited for use during lactation and during pregnancy.

Reviews about Yarina Plus

Reviews about Yarina Plus in the forums are generally positive. Of the concomitant effects, the appearance or elimination of acne, the deterioration or improvement of the condition of the hair and nails are most often noted. Based on the reports of patients, we can say that an unplanned pregnancy, while observing the rules of admission, does not arise.The doctors' comments focus on the presence of calcium levomefolate in the preparation, which reduces the likelihood of fetal development defects in the event that a pregnancy occurred after the withdrawal of Yarina Plus.


Additional Information

SKU fh670
The purpose of the medication Contraception
Weight kg. 0.05

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